First pregnancy, following IVF donated oocytes, in a non-ovarian failure patient. Pregnancy following transfer of in vitro fertilized donated oocytes. Pregnancy after translaparoscopic zygote intrafallopian transfer in a patient with sperm antibodies. Lancet, 7; A laparoscopic approach to a program of gamete intrafallopian transfer. Delivery of twins from frozen human eggs Chen C, Pregnancy after human oocyte cryopreservation. Lancet , 1, — Ultrastructure of the human preovulatory oocyte.
Fertilization of human oocytes by microinjection of a single spermatozoon under the zona pellucida. Two births after microsurgical sperm aspiration in congenital absence of vas deferens. Pregnancy after transfer of sperm under zona.
Implantation of embryos after partial opening of oocyte zona pellucida to facilitate sperm penetration. Lancet, ;16; The death of Dr. Patrick Steptoe -March 21 The Washington Post ,Article: Dr.
The first preclinical evaluation of pronuclear formation by microinjection of human spermatozoa into human oocytes. A preclinical evaluation of pronuclear formation by microinjection of human spermatozoa into human oocytes. First report on biopsy of human preimplantation embryos and sexing by DNA amplification. Biopsy of human preimplantation embryos and sexing by DNA amplification. Micromanipulation of sperm by a laser generated optical trap. Gonen and her colleagues in Toronto pioneered the use of ultrasound for endometrial quality thickness and pattern related to IVF pregnancy.
Endometrial thickness and growth during ovarian stimulation: a possible predictor of implantation in in vitro fertilization. Biopsy of preimplantation mouse embryos: development of micromanipulated embryos and proliferation of single blastomeres in vitro. Biol Reprod. Survival and pregnancy outcome after ultrarapid freezing of human embryos. Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification.
First report of assisted hatching in human embryos. Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulation. Hum Reprod. Analysis of the first polar body: preconception genetic diagnosis. Use of gonadotropin-releasing hormone agonist to trigger follicular maturation for in vitro fertilization. J Clin Endocrinol Metab. Gonen, Jacobson and Casper pioneered the use of combined oral contraceptives for follicle synchronization and cycle scheduling in IVF.
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Discovery that men with congenital absence of the vas deferens have a mild form of cystic fibrosis: Two papers: Anguiano et al. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. JAMA , 12; 6 Ovulation induction by endogenous LH released by the administration of an LHRH agonist after follicular stimulation for in vitro fertilization. Cumulative conception and livebirth rates after in-vitro fertilisation.
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Pregnancy after intracytoplasmic injection of spermatid. Dmitri Dozortsev and coworkers have discovered that oocyte activation during ICSI is triggered by a water-soluble, heat-sensitive, non species specific cytosolic sperm factor.
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In vitro fertilization, or IVF, is one of the most well-known and effective fertility treatments. IVF is a multi-step fertility treatment that assists throughout all stages of conception to maximize the chance of a successful pregnancy.
IVF can address a wide range of fertility problems, including unknown sources of infertility. At the Heartland Center for Reproductive Medicine, PC, our fertility specialists rely on the most advanced technology and the latest IVF techniques to provide our patients with superior treatment. However, each of these technologies and techniques stems from the work of fertility doctors before us.
Here, we discuss the history of IVF, and how it has allowed our Omaha, NE patients to benefit from the safe, reliable, and effective IVF services that are available today. IVF is generally thought of as a newer technique in the field of fertility treatment. However, the history of IVF dates back much further than this. The first experimentations with IVF began in , when Viennese embryologist Samuel Leopold Schenk collected ova from rabbits and guinea pigs.
They also worked with ova collected from rabbits, and introduced sperm to the rabbit eggs while they were outside of the body. In , scientist Min Chueh Chang was able to demonstrate that spermatozoa need to reach a certain phase of maturity before they are ready to be fertilized. Using this information, and the results of the experiments from his predecessors, Chang was finally able to successfully impregnate a rabbit via in vitro fertilization.
Although the IVF procedure was a success, it would still be another 10 years before the technique was applied to people. In , gynecologist Patrick Steptoe teamed up with a professor of human reproduction, Robert Edwards, to attempt the first human pregnancy via IVF. They were able to extract and successfully fertilize multiple mature eggs, but they had trouble implanting the embryos into the female uterus.
Then, in , they began working with an infertile couple, Lesley and John Brown. With this couple, they finally achieved their first successful implantation of a fertilized egg. Lesley became pregnant and gave birth to their daughter, Louise Brown, on July 25, The development of intracytoplasmic sperm injection ICSI has improved success rates. Keywords: Fertility , Fertilization , Reproduction.
In Vitro Fertilization In vitro fertilization IVF is an assisted reproductive technology ART initially introduced by Patrick Steptoe and Robert Edwards in the s to treat female infertility caused by damaged or blocked fallopian tubes. Sources Fishel, S. Malcolm Symonds, eds. Oxford: IRL Press, Marrs, Richard P. Assisted Reproductive Technologies. Boston: Blackwell Scientific Publications, Maienschein, Jane. Whose View of Life?
Trounson, Alan, and Carl Wood. In Vitro Fertilization and Embryo Transfer. Edinburgh, UK: Churchill Livingstone, Printer-friendly version PDF version.
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