When was ivf first introduced




















First pregnancy, following IVF donated oocytes, in a non-ovarian failure patient. Pregnancy following transfer of in vitro fertilized donated oocytes. Pregnancy after translaparoscopic zygote intrafallopian transfer in a patient with sperm antibodies. Lancet, 7; A laparoscopic approach to a program of gamete intrafallopian transfer. Delivery of twins from frozen human eggs Chen C, Pregnancy after human oocyte cryopreservation. Lancet , 1, — Ultrastructure of the human preovulatory oocyte.

Fertilization of human oocytes by microinjection of a single spermatozoon under the zona pellucida. Two births after microsurgical sperm aspiration in congenital absence of vas deferens. Pregnancy after transfer of sperm under zona.

Implantation of embryos after partial opening of oocyte zona pellucida to facilitate sperm penetration. Lancet, ;16; The death of Dr. Patrick Steptoe -March 21 The Washington Post ,Article: Dr.

The first preclinical evaluation of pronuclear formation by microinjection of human spermatozoa into human oocytes. A preclinical evaluation of pronuclear formation by microinjection of human spermatozoa into human oocytes. First report on biopsy of human preimplantation embryos and sexing by DNA amplification. Biopsy of human preimplantation embryos and sexing by DNA amplification. Micromanipulation of sperm by a laser generated optical trap. Gonen and her colleagues in Toronto pioneered the use of ultrasound for endometrial quality thickness and pattern related to IVF pregnancy.

Endometrial thickness and growth during ovarian stimulation: a possible predictor of implantation in in vitro fertilization. Biopsy of preimplantation mouse embryos: development of micromanipulated embryos and proliferation of single blastomeres in vitro. Biol Reprod. Survival and pregnancy outcome after ultrarapid freezing of human embryos. Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification.

First report of assisted hatching in human embryos. Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulation. Hum Reprod. Analysis of the first polar body: preconception genetic diagnosis. Use of gonadotropin-releasing hormone agonist to trigger follicular maturation for in vitro fertilization. J Clin Endocrinol Metab. Gonen, Jacobson and Casper pioneered the use of combined oral contraceptives for follicle synchronization and cycle scheduling in IVF.

Gonadotropin suppression with oral contraceptives before in vitro fertilization. Twin birth after subzonal insemination.

Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program. Fertil Steril Jan;55 1 The fist report suggesting use of the GnRH antagonist, Nal-Glue, to prevent premature LH rise and progesterone in controlled ovarian hyperstimulation treatment.

Prevention of premature luteinizing hormone and progesterone rise with a gonadotropin-releasing hormone antagonist, Nal-Glu, in controlled ovarian hyperstimulation. Technique for cellular microsurgery using the nm excimer laser. Lasers Surg Med. Navot et all. Poor oocyte quality rather than implantation failure as a cause of age-related decline in female fertility.

Ultrasound-guided embryo transfer: a controlled trial. Successful in-vitro fertilisation and embryo transfer after treatment with recombinant human FSH. Assisted zona hatching was introduced in IVF programs to breach the zona pellucida and promote the natural process of hatching. Implantation enhancement by selective assisted hatching using zona drilling of human embryos with poor prognosis.

Discovery that men with congenital absence of the vas deferens have a mild form of cystic fibrosis: Two papers: Anguiano et al. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. JAMA , 12; 6 Ovulation induction by endogenous LH released by the administration of an LHRH agonist after follicular stimulation for in vitro fertilization. Cumulative conception and livebirth rates after in-vitro fertilisation.

Replacement of frozen embryos generated from epididymal spermatozoa: the first two pregnancies. Hum Reprod ;7 5 Erbium YAG laser for micromanipulation of oocytes and spermatozoa. Human recombinant follicle-stimulating hormone induces growth of preovulatory follicles without concomitant increase in androgen and estrogen biosynthesis in a woman with isolated gonadotropin deficiency.

J Clin Endocrinol Metab ; Drukkerij Nauwelaerts, Leuven, Belgium, pp Confirmation that men with congenital absence of the vas defference, have cystic fibrosis mutations which can be transmitted to the offspring Patrizio P, Asch RH, Handelin B, Silber SJ. Aetiology of congenital absence of vas deferens: genetic study of three generations.

Conventional in-vitro fertilization versus intracytoplasmic sperm injection for patients requiring microsurgical sperm aspiration. First established pregnancy and birth after ovarian stimulation with recombinant human follicle stimulating hormone Org The first live birth as a result of IVM following transvaginal ultrasound—guided oocyte collection. In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients.

Fertil Steril ;62 2 Multiple follicular development and ovarian steroidogenesis following subcutaneous administration of a highly purified urinary FSH preparation in pituitary desensitized women undergoing IVF: a multicentre European phase III study. Recombinant human luteinising hormone: an effective new gonadotropin preparation. Lancet ;30; Pregnancies after testicular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermia.

Blastocyst development and birth after in-vitro maturation of human primary oocytes, intracytoplasmic sperm injection and assisted hatching. Assessment of numeric abnormalities of X, Y, 18, and 16 chromosomes in preimplantation human embryos before transfer. Zenzes from the group of Casper in Toronto demonstrated adverse effects of cigarette smoking on nuclear spindle. Cigarette smoking may affect meiotic maturation of human oocytes. The first report in which spermatids were used to achieve pregnancy.

Pregnancy after intracytoplasmic injection of spermatid. Dmitri Dozortsev and coworkers have discovered that oocyte activation during ICSI is triggered by a water-soluble, heat-sensitive, non species specific cytosolic sperm factor.

Human oocyte activation following intracytoplasmic injection: the role of the sperm cell. A prospective, randomized, assessor blind, multicenter study comparing recombinant and urinary follicle-stimulating hormone in in vitro fertilization. Pregnancies after intracytoplasmic sperm injection with cryopreserved testicular spermatozoa. Severe oligozoospermia resulting from deletions of azoospermia factor gene on Y chromosome.

Lancet, , 11; Jurisicova from the Casper group was the first to recognize that preimplantation of human embryo fragmentation involved programmed cell death. Programmed cell death and human embryo fragmentation. Mol Hum Reprod. Casper and his colleagues were the first to demonstrate and introduce the use of the hypo-osmotic swelling test for selection of immotile sperm for ICSI. Casper et al. Birth of infant after transfer of anucleate donor oocyte cytoplasm into recipient eggs.

Lancet, , 19; They showed almost uniform presence of DNA fragmentation in round spermatids as the explanation for failure to achieve pregnancy with these immature gametes. Detection of deoxyribonucleic acid fragmentation in human sperm: correlation with fertilization in vitro.

First births of babies from frozen oocytes following use of ICSI: - Porcu et al, Birth of a healthy female after intracytoplasmic sperm injection of cryopreserved human oocytes. Birth of a healthy female after intracytoplasmic sperm injection of cryopreserved human oocytes.

Falloposcopic GIFT: Births after transcervical gamete intrafallopian transfer with a falloposcopic delivery system. Births after transcervical gamete intrafallopian transfer with a falloposcopic delivery system. Pregnancy after treatment with three recombinant gonadotropins. First established pregnancy after controlled ovarian hyperstimulation with recombinant follicle stimulating hormone and the gonadotrophin-releasing hormone antagonist ganirelix Org A prospective randomized trial of blastocyst culture and transfer in in-vitro fertilization.

Hum Reprod ; Births after intracytoplasmic injection of sperm obtained by testicular extraction from men with nonmosaic Klinefelter's syndrome. Evolution of a culture protocol for successful blastocyst development and pregnancy. First ovum pick-up under 3-D ultrasound vision Feichtinger W. Follicle aspiration with interactive three-dimensional digital imaging Voluson : a step toward real-time puncturing under three-dimensional ultrasound control. In first reports on births from frozen GV eggs, and donor eggs: - Tucker et al.

Birth after cryopreservation of immature oocytes with subsequent in vitro maturation. Clinical application of human egg cryopreservation. First unaffected pregnancy using preimplantation genetic diagnosis for sickle cell anemia. Birth following vitrification of a small number of human oocytes: Case Report. Chian et al. Priming with human chorionic gonadotrophin before retrieval of immature oocytes in women with infertility due to the polycystic ovary syndrome. In vitro fertilization and intracytoplasmic sperm injection pregnancies after successful transport of oocytes by airplane.

In vitro fertilization, or IVF, is one of the most well-known and effective fertility treatments. IVF is a multi-step fertility treatment that assists throughout all stages of conception to maximize the chance of a successful pregnancy.

IVF can address a wide range of fertility problems, including unknown sources of infertility. At the Heartland Center for Reproductive Medicine, PC, our fertility specialists rely on the most advanced technology and the latest IVF techniques to provide our patients with superior treatment. However, each of these technologies and techniques stems from the work of fertility doctors before us.

Here, we discuss the history of IVF, and how it has allowed our Omaha, NE patients to benefit from the safe, reliable, and effective IVF services that are available today. IVF is generally thought of as a newer technique in the field of fertility treatment. However, the history of IVF dates back much further than this. The first experimentations with IVF began in , when Viennese embryologist Samuel Leopold Schenk collected ova from rabbits and guinea pigs.

They also worked with ova collected from rabbits, and introduced sperm to the rabbit eggs while they were outside of the body. In , scientist Min Chueh Chang was able to demonstrate that spermatozoa need to reach a certain phase of maturity before they are ready to be fertilized. Using this information, and the results of the experiments from his predecessors, Chang was finally able to successfully impregnate a rabbit via in vitro fertilization.

Although the IVF procedure was a success, it would still be another 10 years before the technique was applied to people. In , gynecologist Patrick Steptoe teamed up with a professor of human reproduction, Robert Edwards, to attempt the first human pregnancy via IVF. They were able to extract and successfully fertilize multiple mature eggs, but they had trouble implanting the embryos into the female uterus.

Then, in , they began working with an infertile couple, Lesley and John Brown. With this couple, they finally achieved their first successful implantation of a fertilized egg. Lesley became pregnant and gave birth to their daughter, Louise Brown, on July 25, The development of intracytoplasmic sperm injection ICSI has improved success rates. Keywords: Fertility , Fertilization , Reproduction.

In Vitro Fertilization In vitro fertilization IVF is an assisted reproductive technology ART initially introduced by Patrick Steptoe and Robert Edwards in the s to treat female infertility caused by damaged or blocked fallopian tubes. Sources Fishel, S. Malcolm Symonds, eds. Oxford: IRL Press, Marrs, Richard P. Assisted Reproductive Technologies. Boston: Blackwell Scientific Publications, Maienschein, Jane. Whose View of Life?

Trounson, Alan, and Carl Wood. In Vitro Fertilization and Embryo Transfer. Edinburgh, UK: Churchill Livingstone, Printer-friendly version PDF version.



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